b-(4-chloro-2-pyridinyl)boronic acid

b-(4-chloro-2-pyridinyl)boronic acid - Names and Identifiers

Name	(4-Chloro-2-pyridinyl)boronicacid
Synonyms	(4-Chloropyridin-2-yl) (4-Chloropyridin-2-yl)boronic 6-CHLOROPYRIDINE-2-BORONIC ACID 6-Chloropyridin-2-ylboronic acid 4-chloropyridin-2-ylboronic acid (4-Chloro-2-pyridinyl)boronicacid (4-Chloro-2-pyridinyl)boronic acid (4-chloro-2-pyridinyl)boronic acid 6-CHLOROPYRIDIN-2-YL-2-BORONIC ACID b-(4-chloro-2-pyridinyl)boronic acid B-(4-Chloro-2-pyridinyl)boronic acid
CAS	870459-91-9

b-(4-chloro-2-pyridinyl)boronic acid - Physico-chemical Properties

Molecular Formula	C5H5BClNO2
Molar Mass	157.36
Density	1.41
Boling Point	355.2 °C at 760 mmHg
Flash Point	168.6 °C
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

b-(4-chloro-2-pyridinyl)boronic acid - Risk and Safety

Hazard Symbols

Xi - Irritant

b-(4-chloro-2-pyridinyl)boronic acid - Introduction

(4-Chloro-2-pyridinyl)boronicacid is an organic boron compound with the chemical formula C5H4BClNO2. It is a white solid that dissolves in water.

(4-Chloro-2-pyridinyl)boronicacid have important applications in organic synthesis. It can be used as a ligand in copper-catalyzed Sonogashira coupling reactions for the construction of C- C bonds of aromatic compounds. In addition, in the pharmaceutical field, it is also used as an intermediate for the synthesis of some antitumor and antiviral drugs.

A common method for the preparation of (4-Chloro-2-pyridinyl)boronicacid is by oxidation of boronic acid derivatives. First, a compound having a 4-chloropyridine group is reacted with boric acid to form the corresponding boronic acid derivative. The boronic acid derivative is then oxidized to (4-Chloro-2-pyridinyl)boronicacid in a redox reaction.

(4-Chloro-2-pyridinyl)boronicacid is relatively safe under normal operating conditions. However, it is an organic compound and should comply with laboratory safety procedures. During use, care should be taken to avoid inhalation, contact with skin and eyes. In case of accidental contact, rinse immediately with water and seek medical help. At the same time, please keep it in an airtight container, away from heat and fire.

Last Update：2024-04-09 21:11:58